Laboratory for Neurodegenerative Diseases

 

  • Description
    • The laboratory is currently studying how the proteins involve in cell death are regulated in the aging process and how they can be altered by the development of degenerative diseases.

      The activation of caspases—proteins involved in cell death—and the segmentation of specific proteins are crucial in the development of certain neurodegenerative diseases. Research shows that the activation of caspase-6—a kind of "molecular scissors"—occurs early in the neurodegenerative process. It should be noted that caspase-6 activation has been observed in the brains of individuals with Alzheimer's disease and Huntington's disease in the preclinical phase.

      The laboratory is investigating the biology of caspase-6 and the other caspases in order to develop treatments to impede or prevent nerve-cell atrophy. This work will also shed significant light on the mechanisms involved in neurodegenerative diseases as well as help elucidate the crucial factors underlying caspase regulation.

      The goal of the laboratory's research is to define the common and critical steps in the development of neurodegenerative diseases and to help identify treatments that could inhibit or prevent cerebral degeneration.
  • Expertise
      • RNA (quantitative PCR)
      • Protein analysis (Western blot)
      • Immunohistochemistry
      • Caspases
      • Excitotoxicity
      • Olfaction
      • Neurogenesis
      • Animal behavior and neuropathologic studies
      • Molecular/cellular biology, microscopy
  • Researcher
    • Rona K. Graham

 

Coordinator
Perreault, Audrey
819 780-2220 , 45249



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