Laboratory for Lipid Metabolism and Neuroscience


  • Description
    • The laboratory's work focuses on the metabolism of fatty acids during aging and its role in preventing cognitive decline. The researchers involved are particularly interested in the carriers of ApoE4, a genetic factor strongly associated with the risk of developing Alzheimer's disease. ApoE4 carriers do not respond well to omega-3 fatty-acid supplementation, which could make them more vulnerable to developing cognitive decline. The laboratory's research projects aim at determining if the nutritional recommendations related to omega-3 fatty acids need to be adjusted for aging individuals and ApoE4 carriers, since their needs might be different from that of the rest of the population.

      Laboratory researchers are also investigating the relationship between the omega-3 fatty acids supplied to the fetus during pregnancy via cord blood and neurodevelopment upon birth as assessed by electroencephalography. This relationship is assessed both in mothers with gestational diabetes as well as those with type 1 or 2 diabetes before becoming pregnant.
  • Expertise
    • Expertise

      • Near-infrared spectroscopy (NIRS)for the noninvasive assessment of hemoglobin oxygenation in the human brain
      • Molecular-biology techniques to analyze DNA and proteins: Western blot (devices: Chemidoc XRS, Bio-Rad)
      • Quantitative PCR genetic analysis (device: multiplex quantitative PCR)
      • Enzyme assays (device: Perkin Elmer Victor X5)

      Technical Expertise

      • Profiles of fatty acids in plasma, red blood cells, and organs
      • kinetics of fatty acids marked with carbon 13
      • Clinical trials
      • Animal trials

      Scientific Expertise

      • Metabolism and kinetics of fatty acids
      • Build multidisciplinary teams (including physicians and basic scientists) to study newborn age and development
      • Lipids, neuroscience, and lipids in nutrition
  • Researcher
    • Mélanie Plourde
Perreault, Audrey
819 780-2220 , 45249

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