DNA lesions laboratory

 

  • Description
    • This laboratory investigates the biological damage caused by free radicals and oxidants, both exogenous and endogenous. The laboratory is especially interested in damage to DNA, which is significant because of its involvement in many age-related diseases such as cancer and neurodegenerative diseases. The laboratory's researchers are investigating the mechanism of formation of DNA damage and are currently developing new methods for measuring such damage. They apply these analyses to better understand disease etiology or for use as biomarkers. The research team is also looking at the roles that DNA modifications and proteins play in epigenetics. Their work aims at gaining insight into hydroxymethylcytosine depletion in cases of brain cancer as well as other disorders involving neuropathy.

  • Expertise
    • Technical Expertise

      • Extraction of DNA from cells and tissues
      • High-performance liquid chromatography, mass spectrometry, and nuclear magnetic resonance for biomolecular analysis
      • Synthesis of base-modified oligonucleotides and nucleic acids

       Scientific Expertise

      • Nucleic-acid chemistry
      • Reactions of free radicals and antioxidants (e.g., vitamin C)
      • DNA damage and repair
      • Epigenetics
      • Carcinogenesis
  • Researcher
    • Richard Wagner

 

Coordinator
Perreault, Audrey
819 780-2220 , 45249



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